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Genetic Methylation Testing

Unleash the secrets of your DNA with genetic methylation testing – where your genes meet your true potential

Did you know that the well-known biohacker Gary Brecka advocates for methylation testing based on five specific gene mutations?

At My London Skin Clinic, we take this a step further by offering advanced analysis that assesses a total of 10 crucial gene mutations—making it one of the most comprehensive tests available in the middle east.

What is methylation testing and why do I need this?

The Methylation Panel can uncover needs for nutritional support such as amino acids, vitamins, and minerals which are essential in these pathways. However, if your genetic pathway for this specific gene is switched ‘off’, then you may be deficient in certain nutrients, which in turn impact your overall cellular function.

Therefore, after this test we can advise you on which specific nutrients your body lacks and increase supplementation of this, resulting in better cellular function, a reduction in chronic inflammation and overall oxidative stress.

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Methylation plays a role in basic human physiology, so the range of symptoms associated with methylation defects is extensive. The Methylation Panel can offer insights in patients with detoxification pathways, addictions, toxin exposure, cancer risk, cardiovascular disease risk, mood and neurological disorders and cognitive decline.

The Methylation Panel can uncover needs for nutritional support such as amino acids, vitamins, and minerals which are essential in these pathways

Think of these pathways as roads in our body from A to B. Now methylation testing looks to identity a problem in this pathway i.e. a disruption of your normal pathway, at no fault of your own.

These pathways are essentially controlled by Methyl groups, whose main function acts as a switch, turning gene functions on or off. This process plays an important role in cellular functions, such as DNA regeneration, neurotransmitter & energy production, as well as detoxification and improving the ageing process.

Why is our Methylation test the Best in Dubai?

At My London Skin Clinic we aim to provide you with the most extensive screening health programmes in the UAE. Our genetic methylation test includes the following key pathways.

Key pathways looked at:

Genetic Mutation Repsonsible for

BHMT G742A

Betaine-homocysteine S-methyltransferase

 BHMT Is the enzyme responsible for the remethylation of homocysteine

CBS C699T

Cystatione beta synthase

 Involved in glutathione production

GNMT C1289T

Glycine N-methyltransferase pathway

 Involved in antioxidant and detoxification pathways

MAT1A D18777A

Methionine adenosyltransferase pathway

 MAT enzyme requires magnesium as a cofactor and is downregulated by oxidative stress such as alcohol and free radical damage

MTR A2756G

Methionine synthase pathway

 This gene is responsible for converting homocysteine back to methionine

MTRR A66G

Methionine synthase reductase pathway

 This gene is also responsible for converting homocysteine back to methionine

SHMT1 C1240T

Serine hydroxy methyltransferase pathway

 Responsible for maintaining balance of folate groups between the methylation cycle and the folate cycle

MTHFR C677T

5,10 methylenetetrahydrofolate reductase pathway

 Pathway used for homocysteine conversion
Associated with cardiovascular disease, Parkinson’s, diabetes, various types of cancer

MTHFR A1298C

5,10 methylene

 Pathway activates folate, used for homocysteine conversion to methionine
Problems in this pathway associated with CVD, male infertility, certain cancers

COMT V158M

Catechol-O-methyltransferase pathway

 Problems in this pathway associated with increased risk of catecholamines, oestrogens and toxins
Associated with mood disorders, alcoholism, anger, panic disorder & eating disorders

I want a Methylation test, how is it done?

So first you will have a consultation with our Functional Medicine Doctor, who will assess your overall health and wellbeing.

After the consultation there is a simple swab or blood test taken from you and sent to our labs for Methylation analysis.

After the results are back, we will formulate a precise, tailor-made personalised programme for you, which will be discussed in the follow up appointment.

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Frequently Asked Questions

Usually the doctor will do a swab or blood test to take a sample of your DNA for testing in our labs.

It can take anywhere from 3-6 months to correct a problem. I will guide you through a carefully curated tailored made programme using research backed therapies and technology in order to truly improve your health.

The 2 most important nutrients essential for methylation pathways are B12 and folate. Other nutrients such as methionine, cysteine, magnesium, potassium, riboflavin, niacin, pyridoxine and betaine can also impact the pathways so inadequate intake of any of these nutrients can impair methylation. Over and above this toxin exposure, genetic predisposition, environmental factors and chronic stress can affect methylation pathways.

Homocysteine is a type of amino acid that plays a vital role in the metabolism of methionine. Elevated homocysteine levels can indicate impaired methylation, and high levels are in fact associated with cardiovascular disease.

Methylation plays a role in regulating genes associated with ageing. Altered methylation pathways can lead to inappropriate activation or deactivation of genes potentially impacting cellular processes involved in repair and regeneration. Understanding your genetic methylation pathways is the ultimate longevity hack.